What are the most stressful of all situations?

Studies indicate the death of a spouse is one of the single most stressful events anyone can experience. Also very stressful are the death of a close relative, a major injury or illness, and divorce. Surprisingly, mere changes in routine can be harmful. People who deep changing shifts from day to night are more prone to stress than those who always work the same schedule. The disturbing of biological body rhythms takes a high toll.